When taking care of patients at risk of thrombosis a serious complication to treatment with heparins (unfractionated as well as low molecular weight heparins) may occur. This uncommon complication may put your patient at an even higher risk of thrombosis.
The paradox is that the antithrombotic drug used suddenly increases the risk of thrombosis and causes platelet-drop due to an immunologic mechanism.
The challenge with Heparin Induced Thrombocytopenia (HIT) type II is being aware of and recognizing this potentially fatal condition. Making the correct diagnosis and starting appropriate treatment immediately is of vital importance to the affected patient.
Novastan® (argatroban) - Summary of the product characteristics